Article
Agonist-receptor-arrestin, an alternative ternary complex with high agonist affinity.
The Journal of biological chemistry - 14 Nov 1997
Gurevich V V, Pals-Rylaarsdam R, Benovic J L, Hosey M M, Onorato J J
Abstract excerpt
The rapid decrease of a response to a persistent stimulus, often termed desensitization, is a widespread biological phenomenon. Signal transduction by numerous G protein-coupled receptors appears to be terminated by a strikingly uniform two-step mechanism, most extensively characterized for the b...
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