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Article

GRK2-dependent desensitization downstream of G proteins.

Journal of receptor and signal transduction research - 1 Jan 2008

Jurado-Pueyo M, Campos P M, Mayor F, Murga C

Abstract excerpt

G protein-coupled receptor kinases (GRKs) are serine/threonine kinases first discovered by its role in receptor desensitization. Phosphorylation of the C-terminal tail of GPCRs by GRKs triggers the docking of beta-arrestins and the functional uncoupling of G proteins and receptors. In addition, we and others have uncovered new direct ways by which GRKs could impinge into intracellular signalling pathways...

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Source

Identifiers

PMID: 18437630
DOI: 10.1080/10799890801941939

Genes

GRK2
ATF2
CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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