Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation.

The Journal of biological chemistry - 20 Apr 2018

Pack Thomas F, Orlen Margo I, Ray Caroline, Peterson Sean M, Caron Marc G

Abstract excerpt

The dopamine D2 receptor (D2R) is a G protein-coupled receptor (GPCR) that is critical for many central nervous system functions. The D2R carries out these functions by signaling through two transducers: G proteins and β-arrestins (βarrs). Selectively engaging either the G protein or βarr pathway may be a way to improve drugs targeting GPCRs. The current model of GPCR signal transduction posits a chain of events...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pertussis Toxin
Share to beta-Arrestins
Share to Dopamine Agonists

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Energy Transfer

Share to GTP-Binding Proteins

Share to HEK293 Cells

Share to Models, Theoretical

Share to Receptors, Dopamine D2

Source

Open in PubMed Open full text

Identifiers

PMID: 29487132
DOI: 10.1074/jbc.RA117.001300
PMCID: PMC5912473

Genes

GRK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation.PMID 29487132Read ↗

G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor.Semantic proximity Read ↗

G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor.Semantic proximity Read ↗

Distinct CCK-2 receptor conformations associated with β-arrestin-2 recruitment or phospholipase-C activation revealed by a biased antagonist.Semantic proximity Read ↗

G protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation.Semantic proximity Read ↗

Novel features of G protein-coupled receptor kinase 4.Semantic proximity Read ↗

New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signalingSemantic proximity Read ↗

Biased signaling in naturally occurring mutations of G protein-coupled receptors associated with diverse human diseases.Semantic proximity Read ↗

A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity.Semantic proximity Read ↗

GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesitySemantic proximity Read ↗

Mapping the putative G protein-coupled receptor (GPCR) docking site on GPCR kinase 2: insights from intact cell phosphorylation and recruitment assays.Semantic proximity Read ↗

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization.Semantic proximity Read ↗

Advances in the molecular level understanding of G-protein coupled receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.