Article
Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jul 2007
Oakley Robert H, Olivares-Reyes J Alberto, Hudson Christine C, Flores-Vega Fabiola, Dautzenberg Frank M, Hauger Richard L
Abstract excerpt
The primary goal was to test the hypothesis that agonist-induced corticotropin-releasing factor type 1 (CRF(1)) receptor phosphorylation is required for beta-arrestins to translocate from cytosol to the cell membrane. We also sought to determine the relative importance to beta-arrestin recruitment of motifs in the CRF(1) receptor carboxyl terminus and third intracellular loop. beta-Arrestin-2 translocated...
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