Article
The tandem duplicator phenotype as a distinct genomic configuration in cancer.
Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 2016
Menghi Francesca, Inaki Koichiro, Woo XingYi, Kumar Pooja A, Grzeda Krzysztof R, Malhotra Ankit, Yadav Vinod, Kim Hyunsoo, Marquez Eladio J, Ucar Duygu, Shreckengast Phung T, Wagner Joel P, MacIntyre George, Murthy Karuturi Krishna R, Scully Ralph, Keck James, Chuang Jeffrey H, Liu Edison T
Abstract excerpt
Next-generation sequencing studies have revealed genome-wide structural variation patterns in cancer, such as chromothripsis and chromoplexy, that do not engage a single discernable driver mutation, and whose clinical relevance is unclear. We devised a robust genomic metric able to identify cancers with a chromotype called tandem duplicator phenotype (TDP) characterized by frequent and distributed tandem...
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