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Article

Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications.

Cancer research - 1 Apr 2016

Popova Tatiana, Manié Elodie, Boeva Valentina, Battistella Aude, Goundiam Oumou, Smith Nicholas K, Mueller Christopher R, Raynal Virginie, Mariani Odette, Sastre-Garau Xavier, Stern Marc-Henri

Abstract excerpt

CDK12 is a recurrently mutated gene in serous ovarian carcinoma, whose downregulation is associated with impaired expression of DNA damage repair genes and subsequent hypersensitivity to DNA-damaging agents and PARP1/2 inhibitors. In this study, we investigated the genomic landscape associated with CDK12 inactivation in patients with serous ovarian carcinoma. We show that CDK12 loss was consistently associated...

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Share to Cyclin-Dependent Kinases
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PARP1 gene

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Share to Ovarian Neoplasms

Share to Polymorphism, Single Nucleotide

Share to Tandem Repeat Sequences

Source

Identifiers

PMID: 26787835
DOI: 10.1158/0008-5472.CAN-15-2128

Genes

CDK12
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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