Article
High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction.
Nature genetics - 1 Aug 2018
Li Gang, Martínez-Bonet Marta, Wu Di, Yang Yu, Cui Jing, Nguyen Hung N, Cunin Pierre, Levescot Anaïs, Bai Ming, Westra Harm-Jan, Okada Yukinori, Brenner Michael B, Raychaudhuri Soumya, Hendrickson Eric A, Maas Richard L, Nigrovic Peter A
Abstract excerpt
Genome-wide association studies (GWAS) have identified many disease-associated noncoding variants, but cannot distinguish functional single-nucleotide polymorphisms (fSNPs) from others that reside incidentally within risk loci. To address this challenge, we developed an unbiased high-throughput screen that employs type IIS enzymatic restriction to identify fSNPs that allelically modulate the binding of regulatory...
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