Article
Post-GWAS functional studies reveal an RA-associated CD40-induced NF-kB signal transduction and transcriptional regulation network targeted by class II HDAC inhibitors.
Human molecular genetics - 28 May 2021
Zou Meijuan, Jiang Danli, Wu Ting, Zhang Xiaoyu, Zhao Yihan, Wu Di, Sun Wei, Cui Jing, Moreland Larry, Li Gang
Abstract excerpt
Currently, it remains difficult to identify which single nucleotide polymorphisms (SNPs) identified by genome-wide association studies (GWAS) are functional and how various functional SNPs (fSNPs) interact and contribute to disease susceptibility. GWAS have identified a CD40 locus that is associated with rheumatoid arthritis (RA). We previously used two techniques developed in our laboratory, single nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.