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Functional and Computational Interrogation of the Juvenile Idiopathic Arthritis Risk Loci Identifies Candidate Causal SNPs and Target Genes in CD4+ T cells

2025-12-16

Abstract excerpt

<h4>ABSTRACT</h4> GWAS have identified multiple genetic regions that confer risk for juvenile idiopathic arthritis (JIA). However, identifying the single nucleotide polymorphisms (SNPs) that drive disease risk has been impeded by the fact that the SNPs used to identify risk loci are in linkage disequilibrium (LD) with hundreds of other SNPs. Since the causal SNPs remain unknown, it is difficult to identify target...

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Literature Corpus work: e1824032-2e2a-5dab-804b-9cef35a18aca
DOI: 10.64898/2025.12.15.25342296

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