Article

High throughput characterization of genetic effects on DNA:protein binding and gene transcription

2018-02-27

Abstract excerpt

Many variants associated with complex traits are in non-coding regions, and contribute to phenotypes by disrupting regulatory sequences. To characterize these variants, we developed a streamlined protocol for a high-throughput reporter assay, BiT-STARR-seq (Biallelic Targeted STARR-seq), that identifies allele-specific expression (ASE) while accounting for PCR duplicates through unique molecular identifiers. We te...

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Literature Corpus work: 350e83ce-581a-5038-bda9-c31785a98a54
DOI: 10.1101/270991

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