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Article

Functional and computational interrogation of juvenile idiopathic arthritis risk loci in CD4+ T cells.

HGG advances - 9 Jul 2026

Jiang Kaiyu, Haley Emma K, Barshad Gilad, He Adam, Rogic Anita, Rice Edward, Sudman Marc, Thompson Susan D, Murphy David A, Fu Yao, Ponder Lori, Munoz Maurice Davenport, Kolachala Prashant, Prahalad Sampath, Gaffney Patrick M, Danko Charles G, Jarvis James N

Abstract excerpt

Genome-wide association studies (GWASs) have identified multiple genetic regions that confer risk for juvenile idiopathic arthritis (JIA). However, identifying the single-nucleotide polymorphisms (SNPs) that drive disease risk has been impeded by the fact that the SNPs used to identify risk loci are in linkage disequilibrium (LD) with hundreds of other SNPs. Since the causal SNPs remain unknown, it is difficult...

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Share to Arthritis, Juvenile
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42057421
DOI: 10.1016/j.xhgg.2026.100619
PMCID: PMC13214527

Genes

CD4
ERAP2
LNPEP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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