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Article

Modulation of the gamma-secretase activity as a therapy against human hepatocellular carcinoma.

Journal of cancer research and therapeutics - 1 Jun 2018

Shen Yuqing, Yin Ying, Peng Yaqin, Lv Dan, Miao Fengqin, Dou Fei, Zhang Jianqiong

Abstract excerpt

OBJECTIVE: Hepatocellular carcinoma (HCC) is the fifth most common tumor worldwide. The discovery of new therapies against HCC is highly dependable on finding molecules which play essential roles in cancer development. The objective of this study was to evaluate the activity of gamma secretase (γ-secretase), and the antitumor effects of a γ-secretase inhibitor (GSI) in HCC. METHODS: The expression of presenilin 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29970709
DOI: 10.4103/0973-1482.174542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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