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Gamma secretase inhibitors: a patent review (2013 - 2015)

28 Mar 2017

Abstract excerpt

INTRODUCTION: Gamma secretase (GS) is an intricate and multi-subunits complex, and it can cut various transmembrane proteins. Now it is a therapeutic target for a number of diseases. However, due to some side effects, the clinical development of GSI is not successful. Therefore, searching for effective GSIs has become a key point in drug discovery. Areas covered: This review discusses the structure and function...

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PMID: 28350212
DOI: 10.1080/13543776.2017.1313231

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