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Modulation of Oncogenic NOTCH Signaling in Highly Aggressive Malignancies by Targeting the γ-Secretase Complex: A Systematic Review

2026-02-18

Abstract excerpt

<h4>Background: </h4> NOTCH receptors play a pivotal role in carcinogenesis. Upon ligand binding, a cascade of proteolytic cleavages mediated by ADAM proteases and the γ‑secretase complex activates the receptor, ultimately releasing the NOTCH intracellular domain (NICD). NICD translocates to the nucleus, where it regulates gene expression. This review mainly aims to evaluate γ‑secretase inhibitors (GSIs) as antica...

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Literature Corpus work
687f4fb1-7ebb-5592-aed9-c783eca5d408
DOI
10.20944/preprints202511.0585.v4
Open publication

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