Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NOTCH Signaling as a Novel Cancer Therapeutic Target

30 May 2006

Abstract excerpt

NOTCH-ligand interaction is a highly conserved mechanism that regulates specific cell fate decision during development. In addition to its functions in developmental and cell maturation processes, studies indicate that NOTCH activation plays a role in the onset and progression of many human malignancies. The prevailing new strategy for rationally targeted cancer treatment is aimed at the development of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebrovascular and genetic disorders
Share to Nuclear Receptors and Signaling
Share to Protein Tyrosine Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16848722
DOI: 10.2174/156800906777441771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOTCH Signaling as a Novel Cancer Therapeutic TargetPMID 16848722Read ↗

Notch Signaling Proteins: Legitimate Targets for Cancer TherapySemantic proximity Read ↗

More Insights on the Use of γ-Secretase Inhibitors in Cancer Treatment.Semantic proximity Read ↗

NOTCH Signaling Pathway: Occurrence, Mechanism, and NOTCH-Directed Therapy for the Management of CancerSemantic proximity Read ↗

Modulation of Oncogenic NOTCH Signaling in Highly Aggressive Malignancies by Targeting the γ-Secretase Complex: A Systematic ReviewSemantic proximity Read ↗

Notch signaling pathway in cancer: from mechanistic insights to targeted therapiesSemantic proximity Read ↗

Notch Signaling in Cancer: Rationale and Strategies for TargetingSemantic proximity Read ↗

Notch signaling: An emerging therapeutic target for cancer treatmentSemantic proximity Read ↗

Notch Signaling Pathway as a Therapeutic Target in Breast CancerSemantic proximity Read ↗

Modulation of Oncogenic NOTCH Signaling in Highly Aggressive Neoplasia by Targeting the G-Secretase Complex. A Systematic ReviewSemantic proximity Read ↗

Notch Signaling Regulation in HCC: From Hepatitis Virus to Non-Coding RNAsSemantic proximity Read ↗

Notch Pathway: A Journey from Notching Phenotypes to Cancer Immunotherapy.Semantic proximity Read ↗

Targeting Notch signaling pathways with natural bioactive compounds: a promising approach against cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.