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Article

Generation and Characterization of a Novel Knockin Mouse Model Expressing PSEN1 D385A: Implications for Investigating Herbal Drug Effects in γ-Secretase Activity.

Journal of Alzheimer's disease : JAD - 1 Jan 2024

Deng Chengeng, Cai Qingyuan, Zhang Jiani, Chang Kexin, Peng Tiantian, Liu Xiaoge, Cao Feng, Yan Xinyuan, Cheng Junshi, Wang Xu, Tan Yan, Hua Qian

Abstract excerpt

Background: Presenilin (PSEN, PS) is essential for γ-secretase function, and mutations can disrupt amyloid-β (Aβ) production in familial Alzheimer's disease. Targeting γ-secretase is complex due to its broad involvement in physiological processes. Objective: Our aim was to create a novel knockin (KI) mouse model expressing PSEN1 D385A mutation and investigate the efficacy of a Geniposide and Ginsenoside Rg1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38905042
DOI: 10.3233/JAD-231148

Genes

PSEN1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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