Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gamma-secretase inhibitors suppress the growth of leukemia and lymphoma cells.

Oncology reports - 1 Jul 2007

Kogoshi Hanae, Sato Taku, Koyama Takatoshi, Nara Nobuo, Tohda Shuji

Abstract excerpt

gamma-Secretase inhibitors (GSI) suppress the growth of acute T-lymphoblastic leukemia (T-ALL) cells with NOTCH1 mutations. Recently, clinical trials of GSI for refractory T-ALL have commenced. In the present study, we examined the effects of three types of GSI; GSI-I, GSI-IX, and GSI-XII on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid Precursor Protein Secretases
Share to Enzyme Inhibitors
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, B-Cell

Share to Lymphoma, Large B-Cell, Diffuse

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptors, Notch

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 17549349

Genes

HES1
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17549349-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gamma-secretase inhibitors suppress the growth of leukemia and lymphoma cells.PMID 17549349Read ↗

Novel NOTCH1-unmutated T-ALL Cell Line With Suppressed Growth by Gamma-secretase Inhibitors.Semantic proximity Read ↗

Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia CellsSemantic proximity Read ↗

More Insights on the Use of γ-Secretase Inhibitors in Cancer Treatment.Semantic proximity Read ↗

Gamma-secretase inhibitor does not induce cytotoxicity in adult T cell leukemia cell lines despite NOTCH1 overexpressionSemantic proximity Read ↗

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Recent advances on NOTCH signaling in T-ALL.Semantic proximity Read ↗

In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Gamma Secretase Inhibitor: Therapeutic Target via NOTCH Signaling in T Cell Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Targeting the Notch1 and mTOR pathways in a mouse T-ALL modelSemantic proximity Read ↗

The role of NOTCH1 signaling in T-ALL.Semantic proximity Read ↗

Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.