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Article

Notch Signaling Regulation in HCC: From Hepatitis Virus to Non-Coding RNAs

1 Mar 2021

Abstract excerpt

The Notch family includes evolutionary conserved genes that encode for single-pass transmembrane receptors involved in stem cell maintenance, development and cell fate determination of many cell lineages. Upon activation by different ligands, and depending on the cell type, Notch signaling plays pleomorphic roles in hepatocellular carcinoma (HCC) affecting neoplastic growth, invasion capability and stem like...

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PMID: 33804511
DOI: 10.3390/cells10030521

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