Modulation of Oncogenic NOTCH Signaling in Highly Aggressive Neoplasia by Targeting the G-Secretase Complex. A Systematic Review

Abstract excerpt

<h4>Background: </h4> NOTCH receptors play a pivotal role in carcinogenesis. Upon ligand bind-ing, a cascade of proteolytic cleavages mediated by ADAM proteases and -secretase com-plex activates the receptor, culminating in the release of the NOTCH intracellular domain (NICD). NICD translocates to the nucleus, where it modulates gene expression. γ-secretase inhibitors (GSIs) and ADAM secretases inhibitors have em...

Topics

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• Amyloid Precursor Protein Secretases
• Cell Adhesion Molecules Research
• Cell Line, Tumor
• Mutation
• Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
• Receptor, Notch1
• Receptors, Notch
• Signal Transduction

Identifiers and source

Literature Corpus work

53604911-bd7f-5ac0-aede-85ca5189dfd0

DOI

10.20944/preprints202511.0585.v1