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Article

gamma-secretases: from cell biology to therapeutic strategies.

The Lancet. Neurology - 1 Feb 2010

Bergmans Bruno A, De Strooper Bart

Abstract excerpt

Presenilins form the catalytic part of the gamma-secretases, protein complexes that are responsible for the intramembranous cleavage of transmembrane proteins. The presenilins are involved in several biological functions, but are best known for their role in the generation of the beta-amyloid (Ab...

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Identifiers

PMID: 20129170
DOI: 10.1016/S1474-4422(09)70332-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20129170-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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