Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia.

Clinical lymphoma & myeloma - 1 Jan 2009

Palomero Teresa, Ferrando Adolfo

Abstract excerpt

The recent identification of activating mutations in NOTCH1 in the majority of T-cell acute lymphoblastic leukemias (T-ALLs) has brought major interest toward targeting the NOTCH signaling pathway in this disease. Small-molecule gamma-secretase inhibitors (GSIs), which block a critical proteolytic step required for NOTCH1 activation, can effectively block the activity of NOTCH1 mutant alleles. However, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid Precursor Protein Secretases
Share to F-Box Proteins
Share to F-Box-WD Repeat-Containing Protein 7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-myc

Share to Receptor, Notch1

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 19778842
DOI: 10.3816/CLM.2009.s.013
PMCID: PMC2814179

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia.PMID 19778842Read ↗

The role of NOTCH1 signaling in T-ALL.Semantic proximity Read ↗

Recent advances on NOTCH signaling in T-ALL.Semantic proximity Read ↗

Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas.Semantic proximity Read ↗

Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities.Semantic proximity Read ↗

Notch signaling as a therapeutic target for acute lymphoblastic leukemiaSemantic proximity Read ↗

Targeting NOTCH1 in hematopoietic malignancy.Semantic proximity Read ↗

Gamma Secretase Inhibitor: Therapeutic Target via NOTCH Signaling in T Cell Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemiaSemantic proximity Read ↗

More Insights on the Use of γ-Secretase Inhibitors in Cancer Treatment.Semantic proximity Read ↗

T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling.Semantic proximity Read ↗

Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Notch signaling in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.