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Article

Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 2009

Shelton Christopher C, Zhu Lei, Chau Deming, Yang Li, Wang Rong, Djaballah Hakim, Zheng Hui, Li Yue-Ming

Abstract excerpt

gamma-Secretase cleaves multiple substrates within the transmembrane domain that include the amyloid precursor protein as well as the Notch family of receptors. These substrates are associated with Alzheimer disease and cancer. Despite extensive investigation of this protease, little is known reg...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19906985
DOI: 10.1073/pnas.0910757106
PMCID: PMC2787169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19906985-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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