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Article

Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4.

The Journal of biological chemistry - 24 Aug 2018

Rahnamoun Homa, Hong Juyeong, Sun Zhengxi, Lee Jihoon, Lu Hanbin, Lauberth Shannon M

Abstract excerpt

Monomethylation of histone H3 lysine 4 (H3K4me1) is enriched at enhancers that are primed for activation and the levels of this histone mark are frequently altered in various human cancers. Yet, how alterations in H3K4me1 are established and the consequences of these epigenetic changes in tumorigenesis are not well understood. Using ChIP-Seq in human colon cancer cells, we demonstrate that mutant p53 depletion...

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Share to Chromatin
Share to E1A-Associated p300 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Epigenesis, Genetic

Share to Histone-Lysine N-Methyltransferase

Share to Histones

Share to Protein Processing, Post-Translational

Share to Transcriptional Activation

Source

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Identifiers

PMID: 29954944
DOI: 10.1074/jbc.RA118.003387
PMCID: PMC6109924

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