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Article

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

Nature medicine - 1 Jun 2018

Wang Lu, Zhao Zibo, Ozark Patrick A, Fantini Damiano, Marshall Stacy A, Rendleman Emily J, Cozzolino Kira A, Louis Nundia, He Xingyao, Morgan Marc A, Takahashi Yoh-Hei, Collings Clayton K, Smith Edwin R, Ntziachristos Panagiotis, Savas Jeffrey N, Zou Lihua, Hashizume Rintaro, Meeks Joshua J, Shilatifard Ali

Abstract excerpt

The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene enhancers. KMT2C (hereafter referred to as MLL3) frequently incurs point mutations across a range of human tumor types, but precisely how these lesions alter MLL3 function and contribute to oncogenesis is unclear. Here we report a cancer mutational hotspot in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29785026
DOI: 10.1038/s41591-018-0034-6
PMCID: PMC6055231

Genes

BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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