Article

MLL3 regulates the <i>CDKN2A</i> tumor suppressor locus in liver cancer

2022-06-09

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in genes encoding components of chromatin modifying and remodeling complexes are among the most frequently observed somatic events in human cancers. For example, missense and nonsense mutations targeting the mixed lineage leukemia family member 3 ( MLL3 / KMT2C ) histone methyltransferase occur in a range of solid tumors and heterozygous deletions encompassing MLL3 occur in a subset...

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Literature Corpus work: 71497d8e-071b-544c-a452-fd9daf08977e
DOI: 10.1101/2022.06.07.495174

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