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Suppression of ELF4 in ulcerative colitis predisposes host to colorectal cancer

10 Feb 2021

Abstract excerpt

Ulcerative colitis (UC) is a chronic inflammatory bowel disease, characterized by relapsing and remitting colon mucosal inflammation. For patients suffering from UC, a higher risk of colon cancer has been widely recognized. Here, we found that Elf4−/− mice developed colon tumors with 3 cycles of dextran sulfate sodium salt (DSS) treatment alone. We further showed that ELF4 suppression was prevalent in both...

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PMID: 33665583
DOI: 10.1016/j.isci.2021.102169

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