Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

Molecular cell - 18 May 2017

Dorighi Kristel M, Swigut Tomek, Henriques Telmo, Bhanu Natarajan V, Scruggs Benjamin S, Nady Nataliya, Still Christopher D, Garcia Benjamin A, Adelman Karen, Wysocka Joanna

Abstract excerpt

Monomethylation of histone H3 at lysine 4 (H3K4me1) and acetylation of histone H3 at lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but the functional impact of these modifications on enhancer activity is not well understood. Here we used CRISPR/Cas9 genome editing to separate catalytic activity-dependent and independent functions of Mll3 (Kmt2c) and Mll4 (Kmt2d, Mll2), the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Embryonic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Gene Editing

Share to Histone-Lysine N-Methyltransferase

Share to Histones

Share to Methylation

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 28483418
DOI: 10.1016/j.molcel.2017.04.018
PMCID: PMC5662137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.PMID 28483418Read ↗

Enhancer biology and enhanceropathies.Semantic proximity Read ↗

A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping modelSemantic proximity Read ↗

Optimized iMAP CRISPR Perturbation Illuminates the Context-Specific Functions of RNA Modification FactorsSemantic proximity Read ↗

Locus-specific editing of histone modifications at endogenous enhancers.Semantic proximity Read ↗

Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4.Semantic proximity Read ↗

Pathological LSD1 mutations repress enhancer-mediated gene regulatory networks in early differentiationSemantic proximity Read ↗

The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.Semantic proximity Read ↗

Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription.Semantic proximity Read ↗

Tailoring a CRISPR/Cas-based Epigenome Editor for Programmable Chromatin Acylation and Decreased CytotoxicitySemantic proximity Read ↗

Gene regulation: Chromatin editing reveals enhancer targets.Semantic proximity Read ↗

Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations.Semantic proximity Read ↗

The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.