Article

SMAD4 MH2 Mutations Disrupt CREBBP/EP300 Recruitment and TGF-β-Induced Transcription in Colorectal Cancer

2026-07-01

Abstract excerpt

SMAD4 is a central transcriptional effector of the TGF-β signaling pathway and a frequently inactivated tumor suppressor gene in various cancers. Missense mutations in its MH2 domain are among the most prevalent somatic alterations in colorectal cancer (CRC). These mutations are associated with disease progression and poor prognosis, yet their precise mechanistic consequences have remained incompletely characteriz...

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Literature Corpus work: bf007c80-54a4-571a-8df4-66cbd4adb117
DOI: 10.64898/2026.06.30.735541

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