Article
Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.
Cancer research - 1 Feb 2016
Marusiak Anna A, Stephenson Natalie L, Baik Hayeon, Trotter Eleanor W, Li Yaoyong, Blyth Karen, Mason Susan, Chapman Phil, Puto Lorena A, Read Jon A, Brassington Claire, Pollard Hannah K, Phillips Chris, Green Isabelle, Overman Ross, Collier Matthew, Testoni Ewelina, Miller Crispin J, Hunter Tony, Sansom Owen J, Brognard John
Abstract excerpt
MLK4 is a member of the mixed-lineage family of kinases that regulate the JNK, p38, and ERK kinase signaling pathways. MLK4 mutations have been identified in various human cancers, including frequently in colorectal cancer, where their function and pathobiological importance have been uncertain. In this study, we assessed the functional consequences of MLK4 mutations in colon tumorigenesis. Biochemical data...
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