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MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

1 Jun 2023

Abstract excerpt

Mutations in genes encoding components of chromatin modifying and remodeling complexes are among the most frequently observed somatic events in human cancers. For example, missense and nonsense mutations targeting the mixed lineage leukemia family member 3 (MLL3, encoded by KMT2C ) histone methyltransferase occur in a range of solid tumors, and heterozygous deletions encompassing KMT2C occur in a subset of...

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PMID: 37261974
DOI: 10.7554/elife.80854

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