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Article

Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors.

Journal of gastroenterology - 1 Dec 2018

Harada Taku, Yamamoto Eiichiro, Yamano Hiro-O, Aoki Hironori, Matsushita Hiro-O, Yoshikawa Kenjiro, Takagi Ryo, Harada Eiji, Tanaka Yoshihito, Yoshida Yuko, Eizuka Makoto, Yorozu Akira, Sudo Gota, Kitajima Hiroshi, Niinuma Takeshi, Kai Masahiro, Sasaki Yasushi, Tokino Takashi, Sugai Tamotsu, Nakase Hiroshi, Suzuki Hiromu

Abstract excerpt

BACKGROUND: Recent studies revealed that colorectal tumors are composed of genetically diverse subclones. We aimed to clarify whether the surface microstructures of colorectal tumors are associated with genetic intratumoral heterogeneity (ITH). METHODS: The surface microstructures (pit patterns) of colorectal tumors were observed using magnifying endoscopy, and biopsy specimens were obtained from respective areas...

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Identifiers

PMID: 29948303
DOI: 10.1007/s00535-018-1481-z

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KRAS
BRAF

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