Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole Tumor Heterogeneity Topography (WTHT)-A New Approach for Assessment of Intratumor Mutational Heterogeneity in Colorectal Adenomas.

International journal of molecular sciences - 23 Jul 2026

Halkova Tereza, Hodasova Pauerova Lucia, Blechova Karolina, Benesova Tereza, Grega Tomas, Brodyuk Nadija, Traboulsi Eva, Hejcmanova Katerina, Ngo Ondrej, Bures Jan, Suchanek Stepan, Benesova Lucie

Abstract excerpt

Intratumor heterogeneity (ITH) of premalignant colorectal lesions is an important area of research for understanding the diverse biological behavior of colorectal cancer (CRC). Accurate assessment of ITH depends substantially on the sampling strategy used. We present a novel methodological approach termed whole tumor heterogeneity topography (WTHT) and compare it with three previously described sampling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to DNA Mutational Analysis

Share to PIK3CA gene

Share to Genetic Heterogeneity

Share to Mutation

Share to Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 42589206
DOI: 10.3390/ijms27156547
PMCID: PMC13465348

Genes

APC
BRAF
KRAS
PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole Tumor Heterogeneity Topography (WTHT)-A New Approach for Assessment of Intratumor Mutational Heterogeneity in Colorectal Adenomas.PMID 42589206Read ↗

Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors.Semantic proximity Read ↗

Intratumor heterogeneity: A new perspective on colorectal cancer research.Semantic proximity Read ↗

Cancer heterogeneity: implications for targeted therapeuticsSemantic proximity Read ↗

Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer.Semantic proximity Read ↗

Intratumoral Genetic Heterogeneity in Rectal Cancer: Are Single Biopsies representative of the entirety of the tumor?Semantic proximity Read ↗

Understanding Intratumoral Heterogeneity: Lessons from the Analysis of At-Risk Tissue and Premalignant Lesions in the Colon.Semantic proximity Read ↗

A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer.Semantic proximity Read ↗

Intratumoral morphological heterogeneity can be an indicator of genetic heterogeneity in colorectal cancer.Semantic proximity Read ↗

Tumor Heterogeneity in Primary Colorectal Cancer and Corresponding Metastases. Does the Apple Fall Far From the Tree?Semantic proximity Read ↗

Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity.Semantic proximity Read ↗

Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma.Semantic proximity Read ↗

Intra-tumor genetic heterogeneity in rectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.