Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intratumoral Genetic Heterogeneity in Rectal Cancer: Are Single Biopsies representative of the entirety of the tumor?

Annals of surgery - 1 Jan 2017

Bettoni Fabiana, Masotti Cibele, Habr-Gama Angelita, Correa Bruna R, Gama-Rodrigues Joaquim, Vianna Maria R, Vailati Bruna B, São Julião Guilherme P, Fernandez Laura M, Galante Pedro A, Camargo Anamaria A, Perez Rodrigo O

Abstract excerpt

OBJECTIVE: Demonstrate intratumoral genetic heterogeneity in rectal cancer. BACKGROUND: Several clinical management decisions in rectal cancer may be influenced by pretreatment biopsy information. However, in the setting of significant intratumoral heterogeneity, biopsies may not be representative of the entirety of the tumor and limit the reliability of the information provided from them for clinical decision...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Biopsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to DNA, Neoplasm

Share to Genetic Heterogeneity

Share to Rectal Neoplasms

Share to Rectum

Source

Identifiers

PMID: 27479130
DOI: 10.1097/SLA.0000000000001937

Genes

APC
DNAH12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intratumoral Genetic Heterogeneity in Rectal Cancer: Are Single Biopsies representative of the entirety of the tumor?PMID 27479130Read ↗

Intra-tumor genetic heterogeneity in rectal cancer.Semantic proximity Read ↗

Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer.Semantic proximity Read ↗

Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity.Semantic proximity Read ↗

Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures.Semantic proximity Read ↗

Intra-tumoral genomic heterogeneity in rectal cancer: mutational status is dependent on preoperative biopsy depth and location.  Semantic proximity Read ↗

Understanding Intratumoral Heterogeneity: Lessons from the Analysis of At-Risk Tissue and Premalignant Lesions in the Colon.Semantic proximity Read ↗

The Origins and Implications of Intratumor HeterogeneitySemantic proximity Read ↗

Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis.Semantic proximity Read ↗

Optimal detection of clinically relevant mutations in colorectal carcinoma: sample pooling overcomes intra-tumoral heterogeneity.Semantic proximity Read ↗

Unravelling the Complexity of Colorectal Cancer: Heterogeneity, Clonal Evolution, and Clinical ImplicationsSemantic proximity Read ↗

Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors.Semantic proximity Read ↗

Whole Tumor Heterogeneity Topography (WTHT)-A New Approach for Assessment of Intratumor Mutational Heterogeneity in Colorectal Adenomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.