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Article

Colorectal Cancer Genetic Heterogeneity Delineated by Multi-Region Sequencing.

PloS one - 1 Jan 2016

Lu You-Wang, Zhang Hui-Feng, Liang Rui, Xie Zhen-Rong, Luo Hua-You, Zeng Yu-Jian, Xu Yu, Wang La-Mei, Kong Xiang-Yang, Wang Kun-Hua

Abstract excerpt

Intratumor heterogeneity (ITH) leads to an underestimation of the mutational landscape portrayed by a single needle biopsy and consequently affects treatment precision. The extent of colorectal cancer (CRC) genetic ITH is not well understood in Chinese patients. Thus, we conducted deep sequencing by using the OncoGxOne™ Plus panel, targeting 333 cancer-specific genes in multi-region biopsies of primary and liver...

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Source

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Identifiers

PMID: 27023146
DOI: 10.1371/journal.pone.0152673
PMCID: PMC4811559

Genes

NCOR1
SETD2
SMAD4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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