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Article

Distinct molecular features of different macroscopic subtypes of colorectal neoplasms.

PloS one - 1 Jan 2014

Konda Kenichi, Konishi Kazuo, Yamochi Toshiko, Ito Yoichi M, Nozawa Hisako, Tojo Masayuki, Shinmura Kensuke, Kogo Mari, Katagiri Atsushi, Kubota Yutaro, Muramoto Takashi, Yano Yuichiro, Kobayashi Yoshiya, Kihara Toshihiro, Tagawa Teppei, Makino Reiko, Takimoto Masafumi, Imawari Michio, Yoshida Hitoshi

Abstract excerpt

BACKGROUND: Colorectal adenoma develops into cancer with the accumulation of genetic and epigenetic changes. We studied the underlying molecular and clinicopathological features to better understand the heterogeneity of colorectal neoplasms (CRNs). METHODS: We evaluated both genetic (mutations of KRAS, BRAF, TP53, and PIK3CA, and microsatellite instability [MSI]) and epigenetic (methylation status of nine genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25093594
DOI: 10.1371/journal.pone.0103822
PMCID: PMC4122357

Genes

KRAS
BRAF
SFRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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