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Article

Intratumoral morphological heterogeneity can be an indicator of genetic heterogeneity in colorectal cancer.

Experimental and molecular pathology - 1 Feb 2018

Büttner Juliane, Jöhrens Korinna, Klauschen Frederick, Hummel Michael, Lenze Dido, Saeger Wolfgang, Lehmann Annika

Abstract excerpt

Anti-EGFR-targeted therapy is used to treat metastatic colorectal cancers with RAS wild-type. However, resistance to targeted therapy is often observed and can be primary or acquired. One reason for primary resistance is the presence of mutations that are undetected due to genetic heterogeneity, which can be expressed by differences present in primary tumor and distant metastasis or recurrence or by an...

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Identifiers

PMID: 29337243
DOI: 10.1016/j.yexmp.2018.01.007

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EGFR

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