Article
A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma.
The American journal of gastroenterology - 1 Mar 2012
Kimura Tomoaki, Yamamoto Eiichiro, Yamano Hiro-O, Suzuki Hiromu, Kamimae Seiko, Nojima Masanori, Sawada Takeshi, Ashida Masami, Yoshikawa Kenjiro, Takagi Ryo, Kato Ryusuke, Harada Taku, Suzuki Ryo, Maruyama Reo, Kai Masahiro, Imai Kohzoh, Shinomura Yasuhisa, Sugai Tamotsu, Toyota Minoru
Abstract excerpt
OBJECTIVES: Sessile serrated adenomas (SSAs) are known to be precursors of sporadic colorectal cancers (CRCs) with microsatellite instability (MSI), and to be tightly associated with BRAF mutation and the CpG island methylator phenotype (CIMP). Consequently, colonoscopic identification of SSAs has important implications for preventing CRCs, but accurate endoscopic diagnosis is often difficult. Our aim was to...
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