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Article

Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures.

Molecular oncology - 1 Jan 2018

Árnadóttir Sigrid S, Jeppesen Maria, Lamy Philippe, Bramsen Jesper B, Nordentoft Iver, Knudsen Michael, Vang Søren, Madsen Mogens R, Thastrup Ole, Thastrup Jacob, L Andersen Claus

Abstract excerpt

Patient-derived in vitro cultures of colorectal cancer (CRC) may help guide treatment strategies prior to patient treatment. However, most previous studies have been performed on a single biopsy per tumor. The purpose of this study was to analyze multiple spatially distinct biopsies from CRCs and see how well intratumor heterogeneity (ITH) was recapitulated in matching patient-derived spheroids. Three to five...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29130628
DOI: 10.1002/1878-0261.12156
PMCID: PMC5748486

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