Full rescue of an inactive olfactory receptor mutant by elimination of an allosteric ligand-gating site.

Abstract excerpt

Ligand-gating has recently been proposed as a novel mechanism to regulate olfactory receptor sensitivity. TAAR13c, the zebrafish olfactory receptor activated by the death-associated odor cadaverine, appears to possess an allosteric binding site for cadaverine, which was assumed to block progress of the ligand towards the internal orthosteric binding-and-activation site. Here we have challenged the suggested...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Allosteric Site
• Share to Binding Sites
• Share to Ligands