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Article

Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors.

Journal of the American Chemical Society - 8 Jul 2015

de March Claire A, Yu Yiqun, Ni Mengjue J, Adipietro Kaylin A, Matsunami Hiroaki, Ma Minghong, Golebiowski Jérôme

Abstract excerpt

Odorant receptor (OR) genes and proteins represent more than 2% of our genome and 4% of our proteome and constitute the largest subgroup of G protein-coupled receptors (GPCRs). The mechanism underlying OR activation remains poorly understood, as they do not share some of the highly conserved motifs critical for activation of non-olfactory GPCRs. By combining site-directed mutagenesis, heterologous expression, and...

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Identifiers

PMID: 26090619
DOI: 10.1021/jacs.5b04659
PMCID: PMC4497840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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