Article

Allosteric Gating Mechanism Regulates Odorant Selectivity and Antagonism in Odorant Receptors

2026-07-10

Abstract excerpt

Odorant receptors (ORs) belong to class A G protein coupled receptors that detect diverse small molecules, yet the steps that link odorant association to receptor mediated selectivity remains incompletely defined. Here we combined 1.26 milliseconds of all-atom odorant association Molecular Dynamics simulations with Markov state modeling and cell-based cAMP measurements to examine two human ORs receptors that recog...

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Literature Corpus work: 44460a4c-09d8-520a-95a7-c28a0a0c4538
DOI: 10.64898/2026.07.06.736896

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