Article
Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14.
Biochimica et biophysica acta. General subjects - 1 Oct 2018
Nowak Stefanie, Di Pizio Antonella, Levit Anat, Niv Masha Y, Meyerhof Wolfgang, Behrens Maik
Abstract excerpt
BACKGROUND: In humans, bitterness perception is mediated by ~25 bitter taste receptors present in the oral cavity. Among these receptors three, TAS2R10, TAS2R14 and TAS2R46, exhibit extraordinary wide agonist profiles and hence contribute disproportionally high to the perception of bitterness. Perhaps the most broadly tuned receptor is the TAS2R14, which may represent, because of its prominent expression in...
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