Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1

Abstract excerpt

<h4>ABSTRACT</h4> With approximately 400 encoding genes in humans, odorant receptors (ORs) are the largest subfamily of class A G protein-coupled receptors (GPCRs). Despite its high relevance and representation, the odorant-GPCRome is structurally poorly characterized: no experimental structures are available, and the low sequence identity of ORs to experimentally solved GPCRs is a significant challenge for their...

Topics

Open a Topic to create a Post that cites this publication.

• Binding Sites
• Models, Molecular
• Molecular Dynamics Simulation
• Mutation
• Odorants
• Protein Binding
• Protein Conformation
• Receptors, Odorant

Identifiers and source

Literature Corpus work

a3a99f22-a16e-531a-b36b-59f98b67e094

DOI

10.1101/2022.06.01.494157