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Article

Domains for activation and inactivation in G protein-coupled receptors--a mutational analysis of constitutive activity of the adenosine A2B receptor.

Biochemical pharmacology - 15 Nov 2014

Peeters Miriam C, Li Qilan, Elands Rachel, van Westen Gerard J P, Lenselink Eelke B, Müller Christa E, IJzerman Adriaan P

Abstract excerpt

G protein-coupled receptors (GPCRs) are a major drug target and can be activated by a range of stimuli, from photons to proteins. Most, if not all, GPCRs also display a basal level of biological response in the absence of such a stimulus. This level of so-called constitutive activity results from a delicate energy equilibrium that exists between the active and the inactive state of the receptor and is the first...

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Identifiers

PMID: 25179146
DOI: 10.1016/j.bcp.2014.08.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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