Article
What does it take to gate AMPA receptors?
Channels (Austin, Tex.) - 1 Jan 2000
Schmid Sabine M, Hollmann Michael
Abstract excerpt
In vivo, agonist binding to the open conformation of the ligand-binding domain initiates the process of gating in ionotropic glutamate receptors. Arguably, an alternative manner to gate the receptors exists, which requires a point mutation in the most-conserved sequence motif in the second transmembrane domain. Originally, this mutation occurred spontaneously in the orphan glutamate receptor subunit delta2,...
Topics
- Amino Acid Motifs
- Animals
- Gene Expression Regulation
- Ion Channel Gating
- Ligands
- Mice
- Mice, Neurologic Mutants
- Models, Biological
- Mutation
- Phenotype
- Receptors, AMPA
- Receptors, Glutamate