What does it take to gate AMPA receptors?

Abstract excerpt

In vivo, agonist binding to the open conformation of the ligand-binding domain initiates the process of gating in ionotropic glutamate receptors. Arguably, an alternative manner to gate the receptors exists, which requires a point mutation in the most-conserved sequence motif in the second transmembrane domain. Originally, this mutation occurred spontaneously in the orphan glutamate receptor subunit delta2,...

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