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Article

Mutation of the pore glutamate affects both cytoplasmic and external dequalinium block in the rat olfactory CNGA2 channel.

European biophysics journal : EBJ - 1 Jul 2005

Qu Wei, Moorhouse Andrew J, Lewis Trevor M, Pierce Kerry D, Barry Peter H

Abstract excerpt

Dequalinium has recently been reported to block CNGA1 and CNGA2 channels expressed in Xenopus laevis. Using the inside-out configuration of the patch-clamp technique, we examined the effects of dequalinium on rat olfactory CNGA2 channels expressed in human embryonic kidney (HEK293) cells and studied aspects of its molecular mechanism of action. We found that cytoplasmic dequalinium blocked wild-type (WT) CNGA2...

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Source

Identifiers

PMID: 15928936
DOI: 10.1007/s00249-005-0479-7

Genes

CNGA2
CNGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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