Article
Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors.
Proceedings of the National Academy of Sciences of the United States of America - 19 Sept 2006
Kuang Donghui, Yao Yi, Maclean David, Wang Minghua, Hampson David R, Chang Belinda S W
Abstract excerpt
The metabotropic glutamate receptors (mGluRs) within the Family C subclass of G protein-coupled receptors are crucial modulators of synaptic transmission. However, their closest relatives include a diverse group of sensory receptors whose biological functions are not associated with neurotransmission, raising the question of the evolutionary origin of amino acid-binding Family C receptors. A common feature of...
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