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Article

Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling.

Genes & development - 1 Jun 2018

Lanz Michael Charles, Oberly Susannah, Sanford Ethan James, Sharma Sushma, Chabes Andrei, Smolka Marcus Bustamante

Abstract excerpt

The Mec1/ATR kinase coordinates multiple cellular responses to replication stress. In addition to its canonical role in activating the checkpoint kinase Rad53, Mec1 also plays checkpoint-independent roles in genome maintenance that are not well understood. Here we used a combined genetic-phosphoproteomic approach to manipulate Mec1 activation and globally monitor Mec1 signaling, allowing us to delineate distinct...

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Identifiers

PMID: 29899143
DOI: 10.1101/gad.308148.117
PMCID: PMC6049512

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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