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Article

Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.

Molecular biology of the cell - 1 Nov 2005

Nakada Daisuke, Hirano Yukinori, Tanaka Yuya, Sugimoto Katsunori

Abstract excerpt

The large protein kinases, ataxia-telangiectasia mutated (ATM) and ATM-Rad3-related (ATR), coordinate the cellular response to DNA damage. In budding yeast, ATR homologue Mec1 plays a central role in DNA damage signaling. Mec1 interacts physically with Ddc2 and functions in the form of the Mec1-Ddc2 complex. To identify proteins interacting with the Mec1-Ddc2 complex, we performed a modified two-hybrid screen and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16148046
DOI: 10.1091/mbc.e05-05-0405
PMCID: PMC1266421

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.PMID 16148046Read ↗

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