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Article

Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response.

Molecular and cellular biology - 1 Jan 2008

Baldo Veronica, Testoni Valentina, Lucchini Giovanna, Longhese Maria Pia

Abstract excerpt

Eukaryotic genome integrity is safeguarded by two highly conserved protein kinases that are called ATR and ATM for humans and Mec1 and Tel1 for Saccharomyces cerevisiae. Although they share sequence similarities and substrates, these protein kinases perform different specialized functions. In particular, Mec1 plays a key role in the DNA damage checkpoint response, whereas Tel1 primarily is involved in telomere...

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Source

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Identifiers

PMID: 17954565
DOI: 10.1128/MCB.01214-07
PMCID: PMC2223299

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response.PMID 17954565Read ↗

Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.Semantic proximity Read ↗

A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1.Semantic proximity Read ↗

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1.Semantic proximity Read ↗

Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.Semantic proximity Read ↗

Non-catalytic function for ATR in the checkpoint response.Semantic proximity Read ↗

Novel connections between DNA replication, telomere homeostasis, and the DNA damage response revealed by a genome-wide screen for TEL1/ATM interactions in Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA Damage and Replication Stress CheckpointsSemantic proximity Read ↗

Mec1 function in the DNA damage response does not require its interaction with Tel2.Semantic proximity Read ↗

Effects of Saccharomyces cerevisiae mec1, tel1, and mre11 mutations on spontaneous and methylmethane sulfonate-induced genome instability.Semantic proximity Read ↗

A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1.Semantic proximity Read ↗

Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis.Semantic proximity Read ↗

Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.Semantic proximity Read ↗

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